Autologous Biostimulatory Regenerative Therapies
Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) are autologous treatments derived from a patient’s own blood, designed to stimulate cellular regeneration, improve skin texture, and support natural collagen synthesis. Both modalities utilize the regenerative properties of platelets, leukocytes, and growth factors to promote neovascularization, fibroblast activation, and dermal remodeling.
PRP is obtained through high-speed centrifugation, which separates plasma rich in platelets and growth factors from whole blood. Upon injection, platelets degranulate and release bioactive molecules including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and transforming growth factor-beta (TGF-β). These molecules stimulate collagen synthesis, angiogenesis, and cellular proliferation.
PRF, obtained via lower-speed centrifugation without anticoagulants, forms a fibrin matrix that traps platelets, leukocytes, and cytokines. This allows for a slower, sustained release of growth factors, making PRF a second-generation platelet concentrate with prolonged biological activity.
PRP and PRF are indicated for patients seeking non-surgical skin rejuvenation or hair restoration. They can be used alone or in combination with microneedling, lasers, or injectable treatments. Common applications include:
Both PRP and PRF are minimally invasive, low-risk procedures with excellent safety profiles due to their autologous nature. Mild erythema, swelling, or bruising may occur temporarily at the injection site. Outcomes depend on patient age, skin condition, and number of sessions. A series of 3–4 treatments spaced 4–6 weeks apart is typically recommended for optimal results, with maintenance every 6–12 months.
PRP and PRF represent cutting-edge regenerative therapies that harness the body's own cellular signaling to rejuvenate tissue, stimulate collagen, and restore vitality to aging or damaged skin and hair follicles. These treatments offer a safe, natural, and versatile approach to aesthetic medicine.
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